Methyl formate → HCID 67953529, compound

HRID 705938Notes

Reaction equation

HRID 705938 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]([CH3:15])[CH:7]=1.[CH:17](OC)=[O:18].CC(C)([O-])C.[K+]>C1COCC1>[OH:18]/[CH:17]=[C:4](/[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]([CH3:15])[CH:7]=1)\[C:3]([O:2][CH3:1])=[O:16]

Participants

5

Reactant 3

HCID 7865Methyl formateHCID 13679809Methyl 3-(1-methylindol-3-YL)propanoateHCID 23665647Potassium tert-butoxide

Product 1

HCID 67953529HCID 67953529, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the solution of 1-methylindole-3-propionic acid methyl ester (700 mg, 3.22 mmol) and methyl formate (0.397 mL, 6.44 mmol) in THF (20 mL) was added potassium tert-butoxide (723 mg, 6.44 mmol). The mixture was stirred at room temperature for 1 h. concentration in vacuo then afforded the title compound. LCMS: rt=2.81 min, [M+H+]=246

Workup

  1. concentrationconcentration in vacuo

Sources & evidence

ORD record
ord-301ae33714fe45e48e4df224c7b2241a
Source dataset
uspto-grants-2015_11
Patent number
US09174968B2

Reaction notes

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