Trifluoroacetic acid → HCID 67399462, compound

HRID 70597Notes

Reaction equation

HRID 70597 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[CH:11][C:12](/[C:17](/[C:24]2[CH:29]=[CH:28][C:27]([S:30]([N:33]3[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]3)(=[O:32])=[O:31])=[CH:26][CH:25]=2)=[CH:18]/[CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[N:13][C:14]=1[O:15][CH3:16]>C(Cl)(Cl)Cl>[Cl:8][C:9]1[CH:10]=[CH:11][C:12](/[C:17](/[C:24]2[CH:29]=[CH:28][C:27]([S:30]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)(=[O:31])=[O:32])=[CH:26][CH:25]=2)=[CH:18]/[CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[N:13][C:14]=1[O:15][CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67397613tert-butyl 4-({4-[(E)-1-(5-chloro-6-methoxypyridin-2-yl)-2-cyclopentylethenyl]phenyl}sulfonyl)piperazine-1-carboxylate

Product 1

HCID 67399462HCID 67399462, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Trifluoroacetic acid (0.2 mL) was added to a solution of tert-butyl 4-({4-[(E)-1-(5-chloro-6-methoxypyridin-2-yl)-2-cyclopentylethenyl]phenyl}sulfonyl)piperazine-1-carboxylate (178 mg) in chloroform (3 mL), and the mixture was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to give 1-({4-[(E)-1-(5-chloro-6-methoxypyridin-2-yl)-2-cyclopentylethenyl]phenyl}sulfonyl)piperazine as a crude product.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1ac244e76a5f44f680528f21320e1bce
Source dataset
uspto-grants-2014_09
Patent number
US08822503B2

Reaction notes

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