反应详情

温度

60 °C

A mixture of 5-((2-methoxypyrimidin-5-yl)methyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (2.75 g, 10.99 mmol), 1-(chloromethyl)-4-(4-fluorophenoxy)benzene (2.6 g, 10.99 mmol) and diisopropylamine (3.34 g, 33.0 mmol) in DCM (50 mL) was heated at 60° C. overnight. After cooling to room temperature, the mixture was washed with brine, the organic phase was dried over Na2SO4, filtered and concentrated to leave the crude product, which was slurred in EA (20 mL) for 10 min, filtered, washed with EA and concentrated in vacuo to afford the title compound (2.75 g, 51.4% yield) as white solid. LCMS: rt=1.47 min, [M+H]=451.0

1. temperatureAfter cooling to room temperature
2. washthe mixture was washed with brine
3. dry with materialthe organic phase was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customto leave the crude product, which
7. filtrationfiltered
8. washwashed with EA
9. concentrationconcentrated in vacuo