反应详情

温度

60 °C

4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester (60 mg) and Intermediate 2 (60 mg) are dissolved in ethyl acetate, and the mixture is stirred at 60° C. for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the title compound (50 mg).

1. customThe solvent is evaporated under reduced pressure
2. customthe residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)