5-Aminobenzimidazole → HCID 178517664, compound

HRID 706285Notes

Reaction equation

HRID 706285 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.N1([C:16]([N:18]2[CH:22]=[CH:21]N=C2)=[O:17])C=CN=C1.Cl.NCC([C:28]1[CH:33]=[CH:32][C:31]([F:34])=[C:30]([F:35])[CH:29]=1)=O>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[CH:21]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[C:30]([F:35])[CH:29]=4)[CH2:22][NH:18][C:16]3=[O:17])=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

4

Reactant 3

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 44717545HCID 44717545, compound

Product 1

HCID 178517664HCID 178517664, compound

Procedure

The compound was synthesized as hydrochloride salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), di(1H-imidazol-1-yl)methanone (0.713 g, 4.4 mmol), TEA (1.84 mL, 13.2 mmol), aminomethyl-(3,4-difluorophenyl)ketone hydrochloride (0.911 g, 4.4 mmol), TEA (1.23 mL, 8.8 mmol), PdC (10%, 0.02 g) as described in method 1.

Sources & evidence

ORD record
ord-ed777bb1680b4f9bbf4676efd923a444
Source dataset
uspto-grants-2015_11
Patent number
US09173885B2

Reaction notes

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