HCID 13314942, compound → HCID 58046553, compound

HRID 706364Notes

Reaction equation

HRID 706364 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([N:10]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[C:12]3([CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[CH2:11]2)=[O:9])[CH:5]=[CH:4][N:3]=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29](/[C:32](/[Cl:36])=[CH:33]/[CH2:34]Cl)=[CH:28][CH:27]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([N:10]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[C:12]3([CH2:13][CH2:14][N:15]([CH2:34]/[CH:33]=[C:32](/[C:29]4[CH:28]=[CH:27][C:26]([Cl:25])=[CH:31][CH:30]=4)\[Cl:36])[CH2:16][CH2:17]3)[CH2:11]2)=[O:9])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 13314942HCID 13314942, compoundHCID 58046554HCID 58046554, compound

Product 1

HCID 58046553HCID 58046553, compoundYield 64%

Procedure

Alkylation of 1-(2-chloropyridin-4-yl)carbonyl-5-chloro-spiro[indolin-3,4′-piperidine] (0.18 g) with 1-chloro-4-((Z)-1,3-dichloro-propenyl)-benzene obtained in step 3 (0.11 g) was carried out following the procedure described in example 101, step 4 to afford 0.17 g of the title compound (64%) as a foam which was characterized by its mass and NMR spectra. MS (ES+) 548.

Sources & evidence

ORD record
ord-7b2185daaeba48379775b3f63ead26a9
Source dataset
uspto-grants-2015_11
Patent number
US09174987B2

Reaction notes

Loading…