反应详情

温度

55 °C

Crude keto ester 19 (23.6 g, 69 wt %, 16.3 g assay, 39 mmol) was dissolved in DMSO (163 mL) and the solution was added to the reactor over 5-10 min. Then the reaction was heated to 55° C. The pH was adjusted to 10.5 according to a handheld pH meter and controlled overnight with an automated pH controller using 8 M aqueous isopropylamine. The reaction was aged for 27.5 hours.

1. additionthe solution was added to the reactor over 5-10 min
2. customwas adjusted to 10.5 according to a handheld pH meter and controlled overnight with an automated pH controller