HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706371Generated: October 30, 2026
Isopropylamine → tert-Butyl ((5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate
https://huagongshe.com/reaction/706371
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Isopropyl 2-(Boc-amino)-5-oxo-4-(2,3,6-trifluorophenyl)hexanoate | HCID 89814841 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | tert-Butyl ((5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate | HCID 89821820 | — |
Reaction Steps
Crude keto ester 19 (23.6 g, 69 wt %, 16.3 g assay, 39 mmol) was dissolved in DMSO (163 mL) and the solution was added to the reactor over 5-10 min. Then the reaction was heated to 55° C. The pH was adjusted to 10.5 according to a handheld pH meter and controlled overnight with an automated pH controller using 8 M aqueous isopropylamine. The reaction was aged for 27.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174989B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-6dcc19876acc41bb87f05107a98b0c7b |
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| Source note | uspto-grants-2015_11 |
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