Hydrochloric Acid → 3-Ethynylpiperidin-3-ol hydrochloride

HRID 706480Notes

Reaction equation

[C:1]([C:3]1([OH:16])[CH2:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1)#[CH:2].[ClH:17]>>[ClH:17].[C:1]([C:3]1([OH:16])[CH2:8][CH2:7][CH2:6][NH:5][CH2:4]1)#[CH:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 219422481-Boc-3-ethynyl-3-hydroxypiperidine

Product 1

HCID 1181141743-Ethynylpiperidin-3-ol hydrochloride

Procedure

3-Ethynylpiperidin-3-ol hydrochloride was prepared from tert-butyl 3-ethynyl-3-hydroxypiperidine-1-carboxylate and hydrogen chloride using the procedure outlined in Example 3-30.

Sources & evidence

ORD record: ord-a682a887c16b4ff498423c09de412cc0
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09174986B2

Reaction notes

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