反应详情

To ethyl 1-isopropyl-5-methyl-1H-pyrazole-3-carboxylate (7.68 g, 39.1 mmol) in THF (50 mL) at 0° C. was added LAH (1.49 g, 39.1 mmol). The cold bath was removed, and the reaction mixture was stirred for 2 hours, and then quenched carefully with sodium sulfate decahydrate. The reaction mixture was filtered through Celite and washed with Et2O. The filtrate was concentrated under reduced pressure to give 5.3 g (88%) of the title compound.

1. customThe cold bath was removed
2. customquenched carefully with sodium sulfate decahydrate
3. filtrationThe reaction mixture was filtered through Celite
4. washwashed with Et2O
5. concentrationThe filtrate was concentrated under reduced pressure