反应详情

To a solution of sodium hydroxide (2.94 g, 73.6 mmol) in 100 mL of water was added 4-nitro-1H-indazole (3.00 g, 18.39 mmol), followed by sodium hypochlorite (33.4 g, 6.15% aqueous solution). This mixture was allowed to stir at ambient temperature overnight. The mixture was acidified to pH 2 with 10% aqueous HCl and extracted with 25% IPA/DCM. The combined organic extracts were washed with water, dried over sodium sulfate and concentrated under reduced pressure. The resulting solids were triturated with ether to give 1.5 g (41%) of the title compound.

1. extractionextracted with 25% IPA/DCM
2. washThe combined organic extracts were washed with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe resulting solids were triturated with ether