HCID 67976203, compound → HCID 67976239, compound

HRID 706568Notes

Reaction equation

HRID 706568 reaction equation
[CH:1]1([C:6]2[N:11]=[C:10]([CH2:12][N:13]3[C:21]4[C:16](=[C:17]([N+:22]([O-])=O)[CH:18]=[CH:19][CH:20]=4)[C:15]([CH3:25])=[N:14]3)[CH:9]=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>CO.[OH-].[OH-].[Pd+2]>[CH:1]1([C:6]2[N:11]=[C:10]([CH2:12][N:13]3[C:21]4[CH:20]=[CH:19][CH:18]=[C:17]([NH2:22])[C:16]=4[C:15]([CH3:25])=[N:14]3)[CH:9]=[CH:8][CH:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 67976203HCID 67976203, compound

Product 1

HCID 67976239HCID 67976239, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

1-((6-cyclopentylpyridin-2-yl)methyl)-3-methyl-4-nitro-1H-indazole (0.470 g, 1.40 mmol) was dissolved in 14 mL of methanol. To this solution was added 20% Pd(OH)2 (0.470 g, 50% water content) and the reaction mixture was stirred under a hydrogen balloon for 2 hours. This mixture was filtered through GF/F filter paper and the filtrate was concentrated to 0.340 g (79%) of the title compound.

Workup

  1. filtrationThis mixture was filtered through GF/F
  2. filtrationfilter paper
  3. concentrationthe filtrate was concentrated to 0.340 g (79%) of the title compound

Sources & evidence

ORD record
ord-fc3f52bfa6bd4c1e8df06ce0f83acc21
Source dataset
uspto-grants-2015_11
Patent number
US09174981B2

Reaction notes

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