反应详情

温度

50 °C

To a vial was added methyl 3-((4-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)benzoate (Example 93; 0.026 g, 0.0521 mmol) followed by methylamine (0.972 mL, 7.81 mmol, 33% in EtOH) and the mixture was sealed and heated to 50° C. with stirring for 8 hours. Additional methyl amine (0.972 mL, 7.81 mmol) was added and the mixture was stirred at 50° C. overnight. The mixture was cooled to ambient temperature and purified directly by preparative TLC (10% MeOH/CH2Cl2), providing 0.014 g (54%) of the product as a tan powder. MS (ES+APCI) m/z=499 (M+H).

1. customthe mixture was sealed
2. stirringthe mixture was stirred at 50° C. overnight
3. temperatureThe mixture was cooled to ambient temperature
4. custompurified directly by preparative TLC (10% MeOH/CH2Cl2)