反应详情

A solution of 1-benzyl-4-nitro-1H-indazole (0.404 g, 1.595 mmol), ammonium chloride (0.043 g, 0.798 mmol) in 4:1 v/v EtOH/water (10 mL) was treated with iron (0.891 g, 15.95 mmol) and refluxed for 2 hours. The mixture was concentrated and the residue taken in EtOAc/water, filtered through glass fiber filter paper and concentrated again to provide 1-benzyl-1H-indazol-4-amine (0.353 mg, 99% yield).

1. temperaturerefluxed for 2 hours
2. concentrationThe mixture was concentrated
3. filtrationfiltered through glass fiber
4. filtrationfilter paper
5. concentrationconcentrated again