反应详情

To 6-chloropicolinic acid (5.01 g, 31.8 mmol) in EtOH (100 mL) was added concentrated HCl (6 mL, 78 mmol). The reaction was heated to reflux for overnight, cooled to ambient temperature and concentrated under reduced pressure. The residue was dissolved in DCM (100 mL) and NaOH (2M) aqueous solution was added until pH=8. The aqueous layer was then extracted with DCM. The combined organic extracts were combined, dried (Na2SO4) and concentrated under reduced pressure to give the desired product (85%).

1. temperatureThe reaction was heated
2. temperatureto reflux for overnight
3. concentrationconcentrated under reduced pressure
4. dissolutionThe residue was dissolved in DCM (100 mL)
5. additionNaOH (2M) aqueous solution was added until pH=8
6. extractionThe aqueous layer was then extracted with DCM
7. dry with materialdried (Na2SO4)
8. concentrationconcentrated under reduced pressure