反应详情

To ethyl 6-isopropylpicolinate (4.63 g, 24.0 mmol) in THF (50 mL) at 0° C. was added LAH (0.909 g, 24.0 mmol). The cold bath was removed, and the reaction mixture was stirred for 2 hours and quenched carefully with sodium sulfate decahydrate. The reaction mixture was then filtered through Celite® and washed with Et2O (200 mL). The filtrate was concentrated under reduced pressure to give the desired product (86%).

1. customThe cold bath was removed
2. customquenched carefully with sodium sulfate decahydrate
3. filtrationThe reaction mixture was then filtered through Celite®
4. washwashed with Et2O (200 mL)
5. concentrationThe filtrate was concentrated under reduced pressure