反应详情

To 3-bromo-1-((6-isopropylpyridin-2-yl)methyl)-4-nitro-1H-indazole (2.10 g, 5.60 mmol) in EtOH (30 mL) was added Pd(OH)2/C (1.21 g, 1.72 mmol). The reaction mixture purged with N2 and H2 three times each. The reaction was then charged with H2 to 45 psi. The reaction mixture was stirred for 4 hours and filtered through Celite®. The Celite® was washed with EtOH (200 mL) and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (EtOAc/hexane, 2:1) to give the desired product (68%).

1. customThe reaction mixture purged with N2 and H2 three times each
2. additionThe reaction was then charged with H2 to 45 psi
3. filtrationfiltered through Celite®
4. washThe Celite® was washed with EtOH (200 mL)
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was purified by silica gel flash chromatography (EtOAc/hexane, 2:1)