反应详情

To ethyl 1-isopropyl-5-methyl-1H-pyrazole-3-carboxylate (7.68 g, 39.1 mmol) in THF (50 mL) at 0° C. was added LAH (1.49 g, 39.1 mmol). The cold bath was removed, and the reaction mixture was stirred for 2 hours and quenched carefully with sodium sulfate decahydrate. The reaction mixture was filtered through Celite® and washed with Et2O (200 mL). The filtrate was concentrated under reduced pressure to give the desired product (88%).

1. customThe cold bath was removed
2. customquenched carefully with sodium sulfate decahydrate
3. filtrationThe reaction mixture was filtered through Celite®
4. washwashed with Et2O (200 mL)
5. concentrationThe filtrate was concentrated under reduced pressure