反应详情

Added ethyl 7-bromoimidazo[1,2-a]pyridine-3-carboxylate (15 g, 56 mmol) and lithium hydroxide monohydrate (3 g, 71.4 mmol) into tetrahydrofuran/ethanol/water (1:2:1, 560 mL total) solution. After stirring at ambient temperature overnight, the solvent was removed under vacuum to give a yellow gum. Water (300 mL) and dichloromethane was added, and the phases were separated. The aqueous layer was cooled in an ice-water bath before adjusting the pH to 3 using 2N sulfuric acid. The product precipitated out and was collected by filtration and washed with a small amount of water (50 mL) before drying under vacuum to give 7-bromoimidazo[1,2-a]pyridine-3-carboxylic acid as an off-white solid (8.3 g).

1. customthe solvent was removed under vacuum
2. customto give a yellow gum
3. customthe phases were separated
4. temperatureThe aqueous layer was cooled in an ice-water bath
5. customThe product precipitated out
6. filtrationwas collected by filtration
7. washwashed with a small amount of water (50 mL)
8. custombefore drying under vacuum