Hydrazine → HCID 178509222, compound

HRID 706770Notes

Reaction equation

HRID 706770 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[N:23][C:22]([C:25]#[N:26])=[C:21](Cl)[N:20]=2)=[CH:15][CH:14]=1)(=[O:11])=[O:10].[NH2:28][NH2:29]>CC(O)C.O>[NH2:26][C:25]1[C:22]2[C:21](=[N:20][C:19]([C:16]3[CH:15]=[CH:14][C:13]([NH:12][S:9]([C:3]4[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=4[Cl:1])(=[O:10])=[O:11])=[CH:18][CH:17]=3)=[CH:24][N:23]=2)[NH:29][N:28]=1

Participants

5

Reactant 2

HCID 9321HydrazineHCID 866789462,3-dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2-yl)-phenyl]-benzenesulfonamide

Product 1

HCID 178509222HCID 178509222, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Conditions

Temperature
120 °C

Procedure

2,3-Dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2yl)-phenyl]-benzenesulfonamide (1.0 g) was suspended in a mixture of 5 ml iPrOH and 5 ml 35% hydrazine in water at RT and heated to 120° C. by microwave irradiation for 20 min under stirring in a sealed vessel. The reaction mixture was left to cool to RT. The precipitate was filtered off and washed with water to give the title compound as a yellow solid after drying under vacuum. Yield: 536 mg (54%).

Workup

  1. waitThe reaction mixture was left
  2. temperatureto cool to RT
  3. filtrationThe precipitate was filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-844f2163c6174240bd6f982b3c6279a8
Source dataset
uspto-grants-2015_11
Patent number
US09174993B2

Reaction notes

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