反应详情

4-Hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]phenylacetamide (the compound of Example 36) (250 mg) is dissolved in ethyl acetate (10 ml), and thereto is added 10% palladium on carbon (25 mg), and the mixture is subjected to catalytic hydrogenation at 25° C. The catalyst is removed by filtration, and the solvent is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the desired compound (200 mg).

1. customis subjected to catalytic hydrogenation at 25° C
2. customThe catalyst is removed by filtration
3. customthe solvent is evaporated under reduced pressure
4. customThe residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)