Hydrochloric Acid → HCID 178478723, compound

HRID 706862Notes

Reaction equation

HRID 706862 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:21]>ClCCl.CCOCC>[ClH:21].[ClH:21].[O:17]1[CH2:16][CH2:15][N:14]([C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[CH2:19][CH2:18]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178453985HCID 178453985, compound

Product 1

HCID 178478723HCID 178478723, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of trans-tert-butyl-4-morpholinocyclohexylcarbamate (19.2 g, 67.5 mmol) in dichloromethane (100 ml) was added HCl (100 ml, 400 mmol) (4M in dioxane) and the reaction mixture was stirred for 16 hours at room temperature. The reaction mixture was diluted with ether and solid salt was filtered off, and dried in an oven.

Workup

  1. filtrationwas filtered off
  2. customdried in an oven

Sources & evidence

ORD record
ord-2f96759cc142404eb2168cf89dbfe075
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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