Trifluoroacetic acid → HCID 178511581, compound

HRID 706878Notes

Reaction equation

HRID 706878 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@@H:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[O:17]1[CH2:16][CH2:15][N:14]([C@@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453984HCID 178453984, compound

Product 1

HCID 178511581HCID 178511581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 39A (2.43 g) in dichloromethane (15 ml) was added trifluoroacetic acid (5 ml) and the reaction mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated and the crude product was used without purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product was used without purification

Sources & evidence

ORD record
ord-6bccda12ac4a4ba391ade13a7e8f3b63
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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