Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 706908Notes

Reaction equation

HRID 706908 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855, compound

Product 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of EXAMPLE 128A (3.92 g) in ether was added HCl (25 ml, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

Workup

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

Sources & evidence

ORD record
ord-69371b879f1a4e08bbad7614f668a6f3
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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