Trifluoroacetic acid → HCID 53256314, compound

HRID 706912Notes

Reaction equation

HRID 706912 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:11][CH2:10][C@@H:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8]2)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:11][CH2:10][C@@H:9]([NH2:12])[CH2:8]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53256037HCID 53256037, compound

Product 1

HCID 53256314HCID 53256314, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 130A (550 mg) in dichloromethane (25 ml) was cooled in an ice bath under nitrogen. 2,2,2-Trifluoroacetic acid (8.333 ml) was added and the reaction was stirred for 2 hours. The product was obtained by concentration and high vacuum drying.

Workup

  1. customThe product was obtained by concentration and high vacuum
  2. customdrying

Sources & evidence

ORD record
ord-629ce0e03dd74e08b4c1fb365f533280
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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