反应详情

To a solution of 1-tert-butylpiperidin-4-one (5.0 g) in methanol (100 mL) and water (10 mL) was added ammonium formate (20.3 g) and 0.5 g of Pd/C (10%). The mixture was stirred overnight. The mixture was filtered and the filtrate was concentrated under vacuum and the residue was diluted with ethyl acetate (500 mL) and washed with water and brine. After drying over Na2SO4 and filtration, the solvent was evaporated under vacuum to provide the title compound.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated under vacuum
3. additionthe residue was diluted with ethyl acetate (500 mL)
4. washwashed with water and brine
5. dry with materialAfter drying over Na2SO4 and filtration
6. customthe solvent was evaporated under vacuum