反应详情

温度

120 °C

To a suspension of 5-bromo-6-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)pyridine-3-sulfonamide (200 mg) and cyclohexene (0.549 mL) in ethyl acetate (10 mL) was added 10% palladium on carbon (57.6 mg). The suspension was stirred for 60 minutes at 120° C. The reaction mixture was filtered and concentrated. The product was purified by reverse-phase flash chromatography (C18, 15 g, 10%-100% acetonitrile/H2O/trifluoroacetic acid 0.1%).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated
3. customThe product was purified by reverse-phase flash chromatography (C18, 15 g, 10%-100% acetonitrile/H2O/trifluoroacetic acid 0.1%)