Hydrochloric Acid → HCID 67126662, compound

HRID 706965Notes

Reaction equation

HRID 706965 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]1[O:14][CH2:13][CH2:12][N:11]([CH:15]([CH2:18][F:19])[CH2:16][F:17])[CH2:10]1)(C)(C)C.Cl>O1CCOCC1>[F:19][CH2:18][CH:15]([N:11]1[CH2:12][CH2:13][O:14][CH:9]([CH2:8][NH2:7])[CH2:10]1)[CH2:16][F:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 91611602HCID 91611602, compound

Product 1

HCID 67126662HCID 67126662, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of EXAMPLE 252A (538 mg) in dioxane (4 mL) was treated with 4.0M HCl in dioxane solution (1.8 mL). The reaction was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and used without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customused without further purification

Sources & evidence

ORD record
ord-e571a8494ba44106a064d22439d19419
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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