Trifluoroacetic acid → Trifluoroacetic acid

HRID 707149Notes

Reaction equation

HRID 707149 reaction equation
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)=[O:23])=[CH:17][CH:16]=3)[N:12]=[C:11]([N:31]3[CH2:36][CH2:35][CH:34]([NH:37][CH2:38][C:39]([O:41]C(C)(C)C)=[O:40])[CH2:33][CH2:32]3)[N:10]=1)[CH2:2]2.[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49]>ClCCl>[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=4)=[O:23])=[CH:19][CH:20]=3)[N:12]=[C:11]([N:31]3[CH2:36][CH2:35][CH:34]([NH:37][CH2:38][C:39]([OH:41])=[O:40])[CH2:33][CH2:32]3)[N:10]=1)[CH2:2]2.[C:48]([OH:50])([C:47]([F:52])([F:51])[F:46])=[O:49]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67021916HCID 67021916, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67021900HCID 67021900, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 2-(1-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-(3-pyridin-4-ylureido)phenyl)-1,3,5-triazin-2-yl)piperidin-4-ylamino)acetate (28 mg) in dichloromethane (3 mL) was treated with trifluoroacetic acid (1 mL) and then concentrated to dryness to give the title compound as its TFA salt.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-646444fa32f0484a98f4786dc8078a01
Source dataset
uspto-grants-2015_11
Patent number
US09174963B2

Reaction notes

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