Hydrochloric Acid → HCID 86694110, compound

HRID 707230Notes

Reaction equation

HRID 707230 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([CH3:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl>>[Cl:1][C:2]1[C:7]([C:8]([CH3:15])([CH3:14])[C:9]([OH:11])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 86694111HCID 86694111, compound

Product 1

HCID 86694110HCID 86694110, compound

Conditions

Temperature
105 °C

Procedure

Ethyl 2-(2-chloropyridin-3-yl)-2-methylpropanoate (1.43 g, 6.28 mmol) was suspended in concentrated hydrochloric acid (36.5-38.0%, 21.20 mL, 251 mmol) under nitrogen and heated at 105° C. for 20 hours. Additional concentrated hydrochloric acid (15 mL) was added and the reaction heated for another 12 hours. The mixture was concentrated in vacuo and the product was obtained as a brown solid.

Workup

  1. temperaturethe reaction heated for another 12 hours
  2. concentrationThe mixture was concentrated in vacuo
  3. customthe product was obtained as a brown solid

Sources & evidence

ORD record
ord-76c7735d4ee24956a20acdc13905374a
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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