Tert-butyl 2-(3-chloropyrazin-2-yl)-2-methylpropanoate → 2-(3-Chloropyrazin-2-yl)-2-methylpropanoic acid

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Reaction Steps

The tert-butyl ester from step 1 was dissolved in a mixture of dichloromethane (40 mL) and trifluoroacetic acid (20 mL) and heated at reflux. After 4 hours the solution was evaporated to dryness under reduced pressure and purified using silica chromatography (0-10% methanol in dichloromethane gradient) to give 2-(3-chloropyrazin-2-yl)-2-methylpropanoic acid (5.70 g, 28.4 mmol, 59.2% yield) as a tan solid.

Provenance & Evidence