反应详情

The tert-butyl ester from step 1 was dissolved in a mixture of dichloromethane (40 mL) and trifluoroacetic acid (20 mL) and heated at reflux. After 4 hours the solution was evaporated to dryness under reduced pressure and purified using silica chromatography (0-10% methanol in dichloromethane gradient) to give 2-(3-chloropyrazin-2-yl)-2-methylpropanoic acid (5.70 g, 28.4 mmol, 59.2% yield) as a tan solid.

1. temperatureheated
2. temperatureat reflux
3. customAfter 4 hours the solution was evaporated to dryness under reduced pressure
4. custompurified