Hydrochloric Acid → HCID 178426489, compound

HRID 707240Notes

Reaction equation

C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][N:16]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:23]>>[ClH:23].[ClH:23].[CH3:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C@H:11]2[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]2)=[N:16][CH:17]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 178426495HCID 178426495, compound

Product 1

HCID 178426489HCID 178426489, compound

Procedure

Tert-butyl(trans-4-((5-methylpyridin-2-yl)amino)cyclohexyl)carbamate (0.9695 g, 3.17 mmol) and hydrogen chloride (4.0 M solution in 1,4-dioxane, 11.02 ml, 31.7 mmol) to stir at room temperature. After 3½ hours the mixture was evaporated to dryness under reduced pressure. The crude trans-N1-(5-methylpyridin-2-yl)cyclohexane-1,4-diamine dihydrochloride was used without further purification.

Workup

customAfter 3½ hours the mixture was evaporated to dryness under reduced pressure
customThe crude trans-N1-(5-methylpyridin-2-yl)cyclohexane-1,4-diamine dihydrochloride was used without further purification

Sources & evidence

ORD record: ord-02e0de996b554e04b5f29aead3200b09
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09174992B2

Reaction notes

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