HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 45786881, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 4-[(3-nitro-2-pyridinyl)amino]-1-piperidinecarboxylate | HCID 45786870 | — |
| Product | HCID 45786881 | HCID 45786881 | 88% |
Reaction Steps
A mixture of tert-butyl 4-((3-nitropyridin-2-yl)amino)piperidine-1-carboxylate (8.5 g, 26.4 mmol) in hydrogen chloride (4 M solution in methanol, 50 mL) was stirred at room temperature for 3 hours. It was concentrated under reduced pressure to give crude 3-nitro-N-(piperidin-4-yl)pyridin-2-amine hydrochloride (6 g, 23.2 mmol, 88% yield) which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174992B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-1dad50cb58014d6391a76d18ec23eff9 |
| Source note | uspto-grants-2015_11 |