Hydrochloric Acid → HCID 45786881, compound

HRID 707257Notes

Reaction equation

HRID 707257 reaction equation
[N+:1]([C:4]1[C:5]([NH:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[ClH:24]>>[ClH:24].[N+:1]([C:4]1[C:5]([NH:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 457868701,1-Dimethylethyl 4-[(3-nitro-2-pyridinyl)amino]-1-piperidinecarboxylate

Product 1

HCID 45786881HCID 45786881, compoundYield 88%

Procedure

A mixture of tert-butyl 4-((3-nitropyridin-2-yl)amino)piperidine-1-carboxylate (8.5 g, 26.4 mmol) in hydrogen chloride (4 M solution in methanol, 50 mL) was stirred at room temperature for 3 hours. It was concentrated under reduced pressure to give crude 3-nitro-N-(piperidin-4-yl)pyridin-2-amine hydrochloride (6 g, 23.2 mmol, 88% yield) which was used without further purification.

Workup

  1. concentrationIt was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1dad50cb58014d6391a76d18ec23eff9
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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