反应详情

温度

100 °C

To a mixture of potassium carbonate (5.24 mL, 87 mmol) and water (100 mL) and MeOH (400 mL), was added trans-3-((tert-butoxycarbonyl)amino)cyclobutyl 4-nitrobenzoate (17.1 g, 50.8 mmol). The resulting mixture was heated to 100° C. for 2 h, cooled, and filtered. The filtrate was evaporated under vacuum to give the desired product tert-butyl(trans-3-hydroxycyclobutyl)carbamate (4.4 g, 23.50 mmol, 46.2% yield) as a white solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4.73 (br. s., 1 H), 4.39-4.58 (m, 1 H), 4.22 (br. s., 1 H), 2.10-2.48 (m, 5 H), 1.44 (s, 9 H).

1. temperaturecooled
2. filtrationfiltered
3. customThe filtrate was evaporated under vacuum