Hydrochloric Acid → HCID 178479283, compound

HRID 707292Notes

Reaction equation

HRID 707292 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:11][C@H:10]([N:12]2[C:16]3=[N:17][CH:18]=[C:19]([Br:21])[N:20]=[C:15]3[N:14]([CH:22]3[CH2:24][CH2:23]3)[C:13]2=[O:25])[CH2:9]1)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:7][C@H:8]1[CH2:11][C@H:10]([N:12]2[C:16]3=[N:17][CH:18]=[C:19]([Br:21])[N:20]=[C:15]3[N:14]([CH:22]3[CH2:23][CH2:24]3)[C:13]2=[O:25])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178454107HCID 178454107, compound

Product 1

HCID 178479283HCID 178479283, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a room temperature slurry of tert-butyl(trans-3-(5-bromo-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyrazin-1-yl)cyclobutyl)carbamate (0.556 g, 1.31 mmol) in dioxane (10 mL) was added hydrogen chloride, 4.0M solution in 1,4-dioxane (5.0 mL, 20.00 mmol). After stirring overnight the reaction was filtered and the precipitate was washed with Et2O to give 430 mg of a white amorphous solid. ESI MS 323.9, 325.9 [M+1].

Workup

  1. filtrationwas filtered
  2. washthe precipitate was washed with Et2O

Sources & evidence

ORD record
ord-a35cfccda79644e1bc70625bbb7d3c28
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

Loading…