Trifluoroacetic acid → HCID 178511738, compound

HRID 707296Notes

Reaction equation

HRID 707296 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:11][C@H:10]([NH:12][C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:9]1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[S:14]1[C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=[C:13]1[NH:12][C@H:10]1[CH2:9][C@H:8]([NH2:7])[CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454113HCID 178454113, compound2×

Product 1

HCID 178511738HCID 178511738, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)carbamate (intermediate 10, 720 mg, 2.262 mmol) was dissolved in dichloromethane (30 mL) and treated with trifluoroacetic acid (2 mL). The solution was stirred at room temperature for 15 minutes then evaporated to dryness under reduced pressure and further dried under high vacuum. The crude amine salt was used without further purification.

Workup

  1. customthen evaporated to dryness under reduced pressure
  2. customfurther dried under high vacuum
  3. customThe crude amine salt was used without further purification

Sources & evidence

ORD record
ord-1b4af3883ce84492a723bb9818cc5e66
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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