Hydrogen Bromide → HCID 178511736, compound

HRID 707327Notes

Reaction equation

HRID 707327 reaction equation
[O:1]=[C:2]1[N:10]([C@H:11]2[CH2:14][C@H:13]([NH:15]C(=O)OCC3C=CC=CC=3)[CH2:12]2)[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[O:3]1.Br>C(O)(=O)C>[NH2:15][C@H:13]1[CH2:14][C@H:11]([N:10]2[C:5]3=[N:6][CH:7]=[CH:8][CH:9]=[C:4]3[O:3][C:2]2=[O:1])[CH2:12]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 178523832HCID 178523832, compound

Product 1

HCID 178511736HCID 178511736, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of benzyl (trans-3-(2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)cyclobutyl)carbamate (0.225 g, 0.666 mmol) in acetic acid (1 mL) was added hydrogen bromide (33 wt. % in acetic acid, 2 ml, 36.8 mmol). The resulting mixture was stirred at room temperature for 1 hour. The mixture was quenched with addition of 1N sodium hydroxide solution and rotovapped and dried by vacuum pump overnight.

Workup

  1. customThe mixture was quenched with addition of 1N sodium hydroxide solution
  2. customdried by vacuum pump overnight

Sources & evidence

ORD record
ord-27bf9d4bf83b416ba0bb164cd7a15b03
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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