反应详情

Hydrogen chloride (4.0 M in 1,4-dioxane, 1.843 mL, 7.37 mmol) was added to a stirred mixture of tert-butyl(trans-3-(6-fluoro-1-methyl-2-oxo-1H-imidazo[4,5-b]pyridin-3(2H)-yl)cyclobutyl)carbamate (0.248 g, 0.737 mmol) in 1,4-dioxane (3 mL). The reaction mixture was stirred at room temperature for 5 h. The reaction mixture was concentrated to yield 3-(trans-3-aminocyclobutyl)-6-fluoro-1-methyl-1 h-imidazo[4,5-b]pyridin-2(3h)-one hydrochloride (0.210 g, 0.770 mmol, 104% yield) as a white solid. M+1: 237.1.

1. concentrationThe reaction mixture was concentrated