Hydrochloric Acid → HCID 178479281, compound

Participants

Reaction Steps

Hydrogen chloride (4.0 M in 1,4-dioxane, 1.686 mL, 6.74 mmol) was added to a stirred mixture of tert-butyl(trans-3-(3,3,5-trifluoro-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)cyclobutyl)carbamate (0.241 g, 0.674 mmol) in 1,4-dioxane (3 mL). The reaction mixture was stirred at room temperature for 2.5 h. Additional 1,4-dioxane (3 mL) was added, and the reaction mixture was stirred for another 20 h. The reaction mixture was concentrated to yield the title compound (0.210 g, 0.715 mmol, 106% yield) as a white solid. M+1: 258.0.

Provenance & Evidence