Hydrochloric Acid → HCID 178479281, compound

HRID 707407Notes

Reaction equation

HRID 707407 reaction equation
[ClH:1].C(OC(=O)[NH:8][C@H:9]1[CH2:12][C@H:11]([N:13]2[C:17]3=[N:18][CH:19]=[C:20]([F:22])[CH:21]=[C:16]3[C:15]([F:24])([F:23])[C:14]2=[O:25])[CH2:10]1)(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][C@H:9]1[CH2:12][C@H:11]([N:13]2[C:17]3=[N:18][CH:19]=[C:20]([F:22])[CH:21]=[C:16]3[C:15]([F:24])([F:23])[C:14]2=[O:25])[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178454105HCID 178454105, compound

Product 1

HCID 178479281HCID 178479281, compoundYield 106.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Hydrogen chloride (4.0 M in 1,4-dioxane, 1.686 mL, 6.74 mmol) was added to a stirred mixture of tert-butyl(trans-3-(3,3,5-trifluoro-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)cyclobutyl)carbamate (0.241 g, 0.674 mmol) in 1,4-dioxane (3 mL). The reaction mixture was stirred at room temperature for 2.5 h. Additional 1,4-dioxane (3 mL) was added, and the reaction mixture was stirred for another 20 h. The reaction mixture was concentrated to yield the title compound (0.210 g, 0.715 mmol, 106% yield) as a white solid. M+1: 258.0.

Workup

  1. stirringthe reaction mixture was stirred for another 20 h
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d5dbf5e26ea24385a085fd711ec9885f
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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