反应详情

A suspension of lithium aluminum hydride (LAH) (2 g, 52.6 mmol) in dry THF (20 mL) was stirred at room temperature, and a THF solution of substituted malonic acid diethyl ester (26.3 mmol, (5)) was added dropwise. The reaction was allowed to reflux for 3 h and was quenched by the addition of cold water. The compound was extracted in ethyl acetate. The organic layer was washed with water, dried over Na2SO4, and evaporated to produce the product (6) as either a sticky liquid or a low-melting solid.

1. temperatureto reflux for 3 h
2. customwas quenched by the addition of cold water
3. extractionThe compound was extracted in ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialdried over Na2SO4
6. customevaporated