N-chlorosuccinamide → Pyridine-2-carboximidoyl chloride
Reaction equation
C([C:3]1[C:4]([CH:9]=[N:10]O)=[N:5][CH:6]=[CH:7][CH:8]=1)C.[Cl:12]NC(=O)CCC(N)=O>CN(C=O)C>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:3][C:4]=1[C:9]([Cl:12])=[NH:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
To a mixture of ethyl 2-pyridin-aldoxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice-cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.
Workup
- customThe reaction mixture was quenched with ice-cold water (150 ml)
- filtrationThe suspension was filtered
- washthe wet cake washed with small quantity of water
Sources & evidence
- ORD record
- ord-b8551bfae5ee4eb1a2fb451ddede6637
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09175031B2
Reaction notes
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