Water → HCID 68759227, compound

HRID 707645Notes

Reaction equation

HRID 707645 reaction equation
CS(O[CH2:6][C:7]1[CH:11]=[C:10]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[O:9][N:8]=1)(=O)=O.[Br-:18].[Li+].O>CC(C)=O>[Br:18][CH2:6][C:7]1[CH:11]=[C:10]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[O:9][N:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 82050Lithium BromideHCID 86706841HCID 86706841, compound

Product 1

HCID 68759227HCID 68759227, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
30 °C

Procedure

A mixture of 2-(3-methanesulfonyloxymethyl-isoxazol-5-yl)-pyrimidine (19 gm), lithium bromide (13 gm) in acetone (190 ml) was stirred at 30° C. temperature over a period of 2 h. The reaction was monitored by TLC. The reaction mixture was evaporated under vacuum to provide a crude mass which upon stirring with water (150 ml) provided suspension. Filtration of suspension under suction afforded the title compound in 15.2 gm quantity (75.3%) as a solid.

Workup

  1. customThe reaction mixture was evaporated under vacuum
  2. customto provide a crude mass which
  3. customprovided suspension
  4. filtrationFiltration of suspension under suction

Sources & evidence

ORD record
ord-a0025d5200f446b3b5f70dffb4ba94d9
Source dataset
uspto-grants-2015_11
Patent number
US09175031B2

Reaction notes

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