Pyridine 2-aldoxime → Pyridine-2-carboximidoyl chloride
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[N:8]O.[Cl:10]NC(=O)CCC(N)=O>CN(C=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:10])=[NH:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
To a mixture of pyridin-2-carbaldehyde-oxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.
Workup
- customThe reaction mixture was quenched with ice cold water (150 ml)
- filtrationThe suspension was filtered
- washthe wet cake washed with small quantity of water
Sources & evidence
- ORD record
- ord-139f8a6b12f24b56a6b32ee87fd3d9da
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09175031B2
Reaction notes
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