反应详情

Toluene-4-thiosulfonic acid S-(3-chloro-propyl) ester (12.0 g, 45.3 mol, 1.00 eq.), N-ethylisopropylamine (4.2 g, 48.0 mmol, 1.05 eq.) and potassium carbonate (6.9 g, 49.9 mmol, 1.10 eq.) were stirred together in acetonitrile (160 mL) at 60° C. for 18 hours. The mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate (500 mL) and water (250 mL). The organic solution was washed with brine (250 mL), dried (MgSO4) and the resulting oil was purified by MPLC chromatography to give an oil weighing 2.98 g (21%).

1. concentrationThe mixture was concentrated in vacuo
2. customthe residue was partitioned between ethyl acetate (500 mL) and water (250 mL)
3. washThe organic solution was washed with brine (250 mL)
4. dry with materialdried (MgSO4)
5. customthe resulting oil was purified by MPLC chromatography
6. customto give an oil