HRID707829

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID688396

1-[(tert-Butoxycarbonyl)amino]cyclopropane-1-carboxylic acid

C9H15NO4

结构：CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(=O)[C@@H](C)O)C3)ccc1-2

HCID58204116

未命名化合物

PRODUCTS

生成物

结构：CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(=O)C4(NC(=O)OC(C)(C)C)CC4)C3)ccc1-2

HCID67050572

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound was prepared by a similar procedure to (R)-2-hydroxy-1-{3-[2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-azetidin-1-yl}-propan-1-one using 1-(Boc-amino)cyclopropane carboxylic acid and DMF to give (1-{3-[2-(2-Isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-azetidine-1-carbonyl}-cyclopropyl)-carbamic acid tert-butyl ester isolated as a white solid (228 mg, 66%). LCMS: RT=4.72 min, [M+H]+=551

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1519cee7a5584cc09fc317d0320d5127
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09175009B2
来源说明: uspto-grants-2015_11

反应 SMILES

O[C@H](C)C([N:5]1[CH2:8][CH:7]([C:9]2[CH:30]=[CH:29][C:12]3[C:13]4[N:14]=[C:15]([C:21]5[N:22]([CH:26]([CH3:28])[CH3:27])[N:23]=[CH:24][N:25]=5)[S:16][C:17]=4[CH2:18][CH2:19][O:20][C:11]=3[CH:10]=2)[CH2:6]1)=O.[C:32]([NH:39][C:40]1([C:43]([OH:45])=O)[CH2:42][CH2:41]1)([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33]>CN(C=O)C>[C:35]([O:34][C:32](=[O:33])[NH:39][C:40]1([C:43]([N:5]2[CH2:8][CH:7]([C:9]3[CH:30]=[CH:29][C:12]4[C:13]5[N:14]=[C:15]([C:21]6[N:22]([CH:26]([CH3:28])[CH3:27])[N:23]=[CH:24][N:25]=6)[S:16][C:17]=5[CH2:18][CH2:19][O:20][C:11]=4[CH:10]=3)[CH2:6]2)=[O:45])[CH2:41][CH2:42]1)([CH3:36])([CH3:37])[CH3:38]