反应详情

A THF (30 ml) solution of 1-benzyl-4-methylpiperidine-4-carboxamide (2.85 g) was added dropwise over 30 minutes to an ice-cooled suspension of LAH (1.40 g) in THF (50 ml) under a flow of argon gas. After beating the reaction to room temperature and stirring for 1 hour, heating and stirring were performed at 50° C. for 1 hour. The reaction liquid was ice-cooled, and a 90% THF aqueous solution (14 mL), a 15% sodium hydroxide aqueous solution (1.4 mL), and water (4.2 mL) were sequentially added. After stirring the reaction liquid at room temperature for 1 hour, Celite filtration was performed, and the filtrate was concentrated under reduced pressure to obtain 1-(1-benzyl-4-methylpiperidin-4-yl)methanamine (2.68 g).

1. temperaturecooled
2. customthe reaction to room temperature
3. temperatureheating
4. stirringstirring
5. waitwere performed at 50° C. for 1 hour
6. customThe reaction liquid
7. temperaturecooled
8. stirringAfter stirring
9. customthe reaction liquid at room temperature for 1 hour
10. filtrationCelite filtration
11. concentrationthe filtrate was concentrated under reduced pressure