HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperidinecarboxylic acid, 3-fluoro-4-methoxy-4-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (3R,4S)-rel- → HCID 71268706, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperidinecarboxylic acid, 3-fluoro-4-methoxy-4-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (3R,4S)-rel- | HCID 71268704 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 71268706 | HCID 71268706 | 110.6% |
Reaction Steps
20% palladium hydroxide on carbon powder (102 mg) was suspended in a MeOH (29 ml) solution of tert-butyl rel-(3R,4S)-4-[(benzyloxy)methyl]-3-fluoro-4-methoxypiperidine-1-carboxylate (971 mg), and stirring was performed at room temperature under a flow of hydrogen gas for 4 hours. After filtration through Celite, the filtrate was concentrated to obtain tert-butyl rel-(3R,4S)-3-fluoro-4-(hydroxymethyl)-4-methoxypiperidine-1-carboxylate (800 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822688B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-37b11161ef7a43c489c5dec85941b950 |
| Source note | uspto-grants-2014_09 |